ATP-binding cassette (ABC) transporters are proteins found within our cells that transport toxic chemicals out of the cell. Cancer cells over-express these transporters and utilize them to pump out anti-cancer drugs, making cancers resistant to treatment. Selectively shutting down ABC transporters in cancer cells while sparing healthy cells is therefore a promising strategy to attenuate drug resistance, which has been impossible until now. We plan to accomplish this with our expert team, consisting of a cancer biologist (Ambudkar), biomedical engineer (Huang), bioengineering Ph.D. student (Liang), and a CRTA student with a background in biochemistry. We will exploit our combined expertise to develop a mechanism though which light, chemistry, and nanotechnology can be leveraged to shut down ABC transporters in cancer cells while sparing healthy tissues.Comments are closed.
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